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KMID : 0370219960400040438
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Yakhak Hoeji
1996 Volume.40 No. 4 p.438 ~ p.441
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In vivo Efficacy of LB20304a against Experimental Respiratory Tract Infection in Mice
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안미정/Ahn MJ
김무용/백경숙/김인철/곽진환/Kim MY/Paek KS/Kim IC/Kwak JH
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Abstract
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The therapeutic activity of LB20304a was examined on experimental respiratory tract infection (RTI) caused by Klebsiella pneumoniae DT-S in mice. A single oral dose of LB20304a (1.2mg/mouse) showed a rapid bacteriocidal activity in lung tissue at 4,7 and 24h after administration of drug. The in vivo activity of LB20304a was comparable to that of ciprofloxacin against K. pneumoniae infection, although in vitro MIC of LB20304a was four-fold higher than that of ciprofloxacin.
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